Buy Epithalon (Epitalon) for Laboratory Research
Epithalon, also known as Epitalon or Epithalone, is a synthetic tetrapeptide composed of the amino acid sequence Ala-Glu-Asp-Gly (AEDG). Developed as a defined analog of Epithalamin, a peptide extract originally isolated from the bovine pineal gland, Epithalon has become an important investigational compound in peptide research.
Researchers continue to investigate Epithalon in controlled laboratory settings to better understand peptide-mediated signaling pathways associated with telomere biology, cellular communication, neuroendocrine signaling, chromatin regulation, and oxidative stress mechanisms. Published in vitro, animal, and limited clinical studies have made Epithalon a subject of ongoing scientific interest in molecular and cellular research.
Research Use Only. This product is intended exclusively for laboratory and scientific research and is not intended for human or veterinary use.
Overview of Epithalon
Epithalon is a chemically synthesized tetrapeptide designed to provide researchers with a highly defined compound for studying peptide-regulated biological pathways. Its short amino acid sequence allows investigators to evaluate peptide interactions under controlled laboratory conditions with high reproducibility.
Current scientific literature has examined Epithalon in studies involving telomere-associated molecular pathways, chromosomal maintenance, neuroendocrine signaling, oxidative stress-related mechanisms, mitochondrial function, and genomic regulation. Researchers continue investigating these pathways to better understand peptide-mediated cellular responses.
Proposed Mechanism of Action
Although the complete molecular mechanism remains under investigation, published research suggests Epithalon may influence several laboratory pathways associated with:
- Telomerase-associated molecular signaling
- Telomere maintenance research
- Gene expression regulation
- Chromatin-related signaling pathways
- Cellular communication mechanisms
- Oxidative stress-associated molecular responses
- Pineal peptide signaling research
Researchers continue evaluating how Epithalon may influence intracellular signaling networks, peptide-mediated regulation, and molecular responses within controlled experimental models.
Chemical Properties of Epithalon
| Compound Name | Epithalon (Epitalon) |
| Sequence | Ala-Glu-Asp-Gly (AEDG) |
| Molecular Formula | C14H22N4O9 |
| Molecular Weight | 390.35 g/mol |
| PubChem CID | 219042 |
| CAS Number | 307297-39-8 |
| Purity | ≥95% |
| Storage | -20°C |
| Solubility |
DMF: 1 mg/mL DMSO: 3 mg/mL PBS (pH 7.2): 5 mg/mL |
| Shipping | Room temperature within the continental United States (may vary by destination) |
| Synonyms |
Epitalon Epithalon Epithalone AEDG |
Possible Research Applications of Epithalon
1. Telomere Biology Research
Epithalon is frequently investigated in laboratory studies examining telomerase-associated pathways, chromosomal maintenance, cellular senescence, and molecular mechanisms related to telomere biology.
2. Neuroendocrine & Pineal Signaling Research
Researchers utilize Epithalon to investigate peptide-mediated signaling associated with pineal gland biology, circadian-related pathways, and neuroendocrine communication.
3. Oxidative Stress Research
Epithalon has been examined in experimental models evaluating oxidative stress-associated signaling pathways, mitochondrial function, redox balance, and antioxidant-related molecular mechanisms.
4. Genomic & Chromatin Research
Current investigations continue exploring Epithalon’s potential role in gene expression regulation, chromatin-associated signaling, and molecular pathways involved in cellular communication.
5. Peptide Biology Research
Epithalon remains an important investigational peptide for studying peptide structure, molecular interactions, intracellular signaling pathways, and laboratory-based peptide biology.
Laboratory Storage & Handling
Epithalon is supplied as a lyophilized powder for laboratory research applications.
- Store lyophilized material at -20°C, protected from moisture and light.
- After reconstitution, store according to validated laboratory procedures.
- Avoid repeated freeze-thaw cycles.
- Wear appropriate laboratory PPE including gloves, eye protection, and a lab coat.
- Consult the Safety Data Sheet (SDS) before handling.
- Dispose of unused material according to institutional laboratory regulations.
Why Buy Epithalon from PureRawz?
Every batch of Epithalon undergoes rigorous quality control through both internal and independent third-party analytical testing. Batch-specific Certificates of Analysis (COA) are available to verify compound identity, purity, and analytical performance before laboratory use.
Analytical testing may include:
- High-Performance Liquid Chromatography (HPLC)
- Mass Spectrometry (MS)
- Identity Verification
- Batch Consistency Testing
- Purity Analysis
Frequently Asked Questions
What is Epithalon made of?
Epithalon is a synthetic tetrapeptide consisting of alanine, glutamic acid, aspartic acid, and glycine (AEDG).
How is Epithalon supplied?
Epithalon is commonly supplied as a lyophilized (freeze-dried) powder for laboratory preparation and storage.
How is Epithalon purity verified?
Quality testing commonly includes analytical techniques such as HPLC and mass spectrometry to verify identity, purity, and batch consistency.
Why is batch consistency important?
Consistent manufacturing and analytical testing help researchers obtain reproducible materials suitable for controlled laboratory investigations.
Can Epithalon be used for human consumption?
No. Epithalon is intended strictly for laboratory research purposes and is not approved for human or veterinary use.
Research Use Disclaimer
The information provided is for educational and scientific purposes only and should not be interpreted as medical advice, diagnosis, or treatment recommendations.
Products sold by PureRawz are intended solely for laboratory and research applications. They are not FDA-approved drugs, dietary supplements, foods, cosmetics, or medical devices and are not intended for human or veterinary consumption.
Researchers are responsible for complying with all institutional, local, state, and federal regulations governing laboratory research, including applicable IRB and IACUC requirements.
ATTENTION: ALL PRODUCTS ARE FOR LABORATORY RESEARCH PURPOSES ONLY. NOT FOR HUMAN OR VETERINARY USE.
References
- Al-dulaimi S, Thomas R, Matta S, Roberts T. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. 2025.
- Khavinson VK, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003.
- Korkushko OV, Khavinson VK, Shatilo VB, Antonyk-Sheglova IA. Peptide geroprotector from the pineal gland of animals normalizes the daily melatonin rhythm in elderly people. Bull Exp Biol Med. 2007.
- Araj W, Łos-Rycharska E, Malinowski J, et al. Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025.
- Avolio E, Martinotti S, Khavinson VK, et al. Peptides Regulating Proliferation and Survival of Basal Forebrain Cholinergic Neurons as Potential Therapeutic Lead Molecules. Int J Mol Sci. 2022.
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